Article
erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling.
Oncogene - 1 Jul 1992
Segatto O, Lonardo F, Helin K, Wexler D, Fazioli F, Rhee S G, Di Fiore P P
Abstract excerpt
Autophosphorylation of gp185erbB-2 in vivo is confined to its carboxy terminus and is required for optimal erbB-2 transforming activity under conditions of receptor overexpression. It remains unresolved, however, to what extent autophosphorylation regulates erbB-2 mitogenic signaling in normal cells, nor is the biochemical basis for such a regulatory function known. To address these issues, we utilized a chimeric...
Topics
- Amino Acid Sequence
- Cell Line
- ErbB Receptors
- Growth Substances
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Receptor, ErbB-2
- Recombinant Fusion Proteins