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Article

erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling.

Oncogene - 1 Jul 1992

Segatto O, Lonardo F, Helin K, Wexler D, Fazioli F, Rhee S G, Di Fiore P P

Abstract excerpt

Autophosphorylation of gp185erbB-2 in vivo is confined to its carboxy terminus and is required for optimal erbB-2 transforming activity under conditions of receptor overexpression. It remains unresolved, however, to what extent autophosphorylation regulates erbB-2 mitogenic signaling in normal cells, nor is the biochemical basis for such a regulatory function known. To address these issues, we utilized a chimeric...

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Source

Identifiers

PMID: 1352397

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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