Domain-specific interactions between the p185(neu) and epidermal growth factor receptor kinases determine differential signaling outcomes.

doi:10.1074/jbc.274.2.574

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Article

Domain-specific interactions between the p185(neu) and epidermal growth factor receptor kinases determine differential signaling outcomes.

The Journal of biological chemistry - 8 Jan 1999

Qian X, O'Rourke D M, Fei Z, Zhang H T, Kao C C, Greene M I

Abstract excerpt

We expressed the epidermal growth factor receptor (EGFR) along with mutant p185(neu) proteins containing the rat transmembrane point mutation. The work concerned the study of the contributions made by various p185(neu) subdomains to signaling induced by a heterodimeric ErbB complex. Co-expression...

Topics

Animals
COS Cells
Cell Division
Cell Membrane
Dimerization
Down-Regulation
ErbB Receptors
Mice
Mutation
Phosphatidylinositol 3-Kinases
Receptor, ErbB-2
Signal Transduction

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