A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.

doi:10.1128/mcb.12.1.128-135.1992

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Article

A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.

Molecular and cellular biology - 1 Jan 1992

Vega Q C, Cochet C, Filhol O, Chang C P, Rhee S G, Gill G N

Abstract excerpt

Cells expressing mutant epidermal growth factor (EGF) receptors have been used to study mechanisms through which EGF increases phospholipase C (PLC) activity. C-terminal truncation mutant EGF receptors are markedly impaired in their ability to increase inositol phosphate formation compared with w...

Topics

Animals
Cell Line
Enzyme Activation
ErbB Receptors
Humans
Inositol Phosphates
Kinetics
Mice
Mutation
Phosphorylation
Type C Phospholipases
Tyrosine

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