Article
Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding.
The Journal of biological chemistry - 14 Jul 1995
Touhara K, Koch W J, Hawes B E, Lefkowitz R J
Abstract excerpt
The beta gamma subunits of heterotrimeric G proteins (G beta gamma) play a variety of roles in cellular signaling, one of which is membrane targeting of the beta-adrenergic receptor kinase (beta ARK). This is accomplished via a physical interaction of G beta gamma and a domain within the carboxyl...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Biological Transport
- Blood Proteins
- Cattle
- Cyclic AMP-Dependent Protein Kinases
- GTP-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Phosphatidylinositol 4,5-Diphosphate
- Phosphatidylinositol Phosphates
- Phosphoproteins
- Recombinant Fusion Proteins
- beta-Adrenergic Receptor Kinases