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Article

Activated EGF receptor may balance ERK-inhibitory network signalling pathways.

Cellular signalling - 1 Jul 2006

Hanke Sabine, Valkova Christina, Stirnweiss Jörg, Drube Sebastian, Liebmann Claus

Abstract excerpt

In the COS-7 cell signalling network high levels of cAMP produced, for example, by co-stimulation of beta2-adrenergic receptor (beta2-AR) and bradykinin B2 receptor (BKR) may affect epidermal growth factor receptor (EGFR)-mediated activation of extracellular signal-stimulated kinase (ERK). In contrast, co-stimulation of either beta2-AR or B2R with EGFR leads to synergistic activation of ERK. Due to triple...

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Source

Identifiers

PMID: 16226010
DOI: 10.1016/j.cellsig.2005.08.019

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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