Article
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.
Molecular and cellular biology - 1 Feb 1990
Margolis B, Bellot F, Honegger A M, Ullrich A, Schlessinger J, Zilberstein A
Abstract excerpt
Epidermal growth factor (EGF) treatment of NIH 3T3 cells transfected with wild-type EGF receptor induced tyrosine phosphorylation of phospholipase C-gamma (PLC-gamma). The EGF receptor and PLC-gamma were found to be physically associated such that antibodies directed against PLC-gamma or the EGF...
Topics
- Animals
- Cells, Cultured
- Epidermal Growth Factor
- ErbB Receptors
- Gene Expression
- Genes
- Humans
- Kinetics
- Mice
- Mice, Inbred Strains
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Transfection
- Type C Phospholipases