Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex.

doi:10.1128/mcb.10.5.2359-2366.1990

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Article

Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex.

Molecular and cellular biology - 1 May 1990

Morrison D K, Kaplan D R, Rhee S G, Williams L T

Abstract excerpt

We investigated the interaction of phospholipase C-gamma (PLC-gamma) with wild-type and mutant forms of the platelet-derived growth factor (PDGF) beta-receptor both in vivo and in vitro. After PDGF treatment of CHO cell lines expressing wild-type or either of two mutant (delta Ki and Y825F) PDGF receptors, PLC-gamma became tyrosine phosphorylated and associated with the receptor proteins. The receptor association...

Topics

Animals
Cell Line
Cricetinae
In Vitro Techniques
Macromolecular Substances
Mice
Mutation
Phosphoric Monoester Hydrolases
Phosphotyrosine
Platelet-Derived Growth Factor
Precipitin Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinases

Protein-Tyrosine Kinases

Receptors, Cell Surface

Receptors, Platelet-Derived Growth Factor

Signal Transduction

Type C Phospholipases

Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 1691440
DOI: 10.1128/mcb.10.5.2359-2366.1990
PMCID: PMC360584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1691440-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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