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Article

The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation.

The Journal of biological chemistry - 9 Aug 2002

Huang Qunhua, Lerner-Marmarosh Nicole, Che Wenyi, Ohta Shinsuke, Osawa Masaki, Yoshizumi Masanori, Glassman Michael, Yan Chen, Berk Bradford C, Abe Jun-Ichi

Abstract excerpt

SHP-2, a nontransmembrane-type protein-tyrosine phosphatase that contains two Src homology 2 (SH2) domains, is thought to participate in growth factor signal transduction pathways via SH2 domain interactions. To determine the role of each region of SHP-2 in platelet-derived growth factor signaling assayed by Elk-1 activation, we generated six deletion mutants of SHP-2. The large SH2 domain deletion SHP-2 mutant...

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PMID: 12011040
DOI: 10.1074/jbc.M112450200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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