Article
The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.
Molecular and cellular biology - 1 Jun 1995
Valius M, Secrist J P, Kazlauskas A
Abstract excerpt
The beta receptor for platelet-derived growth factor (beta PDGFR) is activated by binding of PDGF and undergoes phosphorylation at multiple tyrosine residues. The tyrosine-phosphorylated receptor associates with numerous SH2-domain-containing proteins which include phospholipase C-gamma 1 (PLC gamma), the GTPase-activating protein of Ras (GAP), the p85 subunit of phosphatidylinositol 3 kinase (PI3K), the...
Topics
- Binding Sites
- Cell Line
- GTPase-Activating Proteins
- Humans
- Isoenzymes
- Mutation
- Phospholipase C gamma
- Phosphorylation
- Proteins
- Receptor, Platelet-Derived Growth Factor beta
- Receptors, Platelet-Derived Growth Factor