Article
Src homology region 2 domains direct protein-protein interactions in signal transduction.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1990
Moran M F, Koch C A, Anderson D, Ellis C, England L, Martin G S, Pawson T
Abstract excerpt
Cytoplasmic proteins that regulate signal transduction or induce cellular transformation, including cytoplasmic protein-tyrosine kinases, p21ras GTPase-activating protein (GAP), phospholipase C gamma, and the v-crk oncoprotein, possess one or two copies of a conserved noncatalytic domain, Src hom...
Topics
- Animals
- Binding Sites
- Cell Line
- GTPase-Activating Proteins
- Genes, src
- Humans
- Mutation
- Oncogene Protein v-crk
- Protein-Tyrosine Kinases
- Proteins
- Proto-Oncogene Proteins p21(ras)
- Rats
- Retroviridae Proteins, Oncogenic
- Sequence Homology, Nucleic Acid
- Signal Transduction