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Article

Src homology region 2 domains direct protein-protein interactions in signal transduction.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1990

Moran M F, Koch C A, Anderson D, Ellis C, England L, Martin G S, Pawson T

Abstract excerpt

Cytoplasmic proteins that regulate signal transduction or induce cellular transformation, including cytoplasmic protein-tyrosine kinases, p21ras GTPase-activating protein (GAP), phospholipase C gamma, and the v-crk oncoprotein, possess one or two copies of a conserved noncatalytic domain, Src homology region 2 (SH2). Here we provide direct evidence that SH2 domains can mediate the interactions of these diverse...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 2236073
DOI: 10.1073/pnas.87.21.8622
PMCID: PMC55009

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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