Article
Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.
Oncogene - 1 Dec 1994
Li N, Schlessinger J, Margolis B
Abstract excerpt
Many growth factors bind and activate receptors with intrinsic protein tyrosine kinase activity. Once activated these receptors undergo autophosphorylation allowing them to bind src homology 2 (SH2) domain proteins. We mutated or deleted all known autophosphorylation sites of the Epidermal Growth...
Topics
- 3T3 Cells
- Adaptor Proteins, Signal Transducing
- Animals
- Base Sequence
- Enzyme Activation
- ErbB Receptors
- GRB2 Adaptor Protein
- Humans
- Membrane Proteins
- Mice
- Mitogen-Activated Protein Kinase 1
- Mitosis
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Oncogene Protein pp60(v-src)
- Phosphorylation
- Protein Serine-Threonine Kinases