Article
Revertants of v-fos-transformed rat fibroblasts: suppression of transformation is dominant.
Molecular and cellular biology - 1 Nov 1990
Wisdom R, Verma I M
Abstract excerpt
Phenotypic revertants of Finkel-Biskis-Riley (FBR)-murine sarcoma virus-transformed rat fibroblasts were isolated on the basis of their adherence to plastic tissue culture dishes in the absence of divalent cations. Some revertants had sustained deletions or inactivating mutations of the v-fos gene. However, two revertants expressed a functional v-fos gene at levels equal to that in the transformed parental cells,...
Topics
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Chromosome Deletion
- Mice
- Oncogene Proteins v-fos
- Oncogene Proteins, Viral
- Phenotype
- Protein-Tyrosine Kinases
- Proto-Oncogenes
- RNA, Messenger