Overexpression of avian or mouse c-jun in primary chick embryo fibroblasts confers a partially transformed phenotype.

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Article

Overexpression of avian or mouse c-jun in primary chick embryo fibroblasts confers a partially transformed phenotype.

Oncogene - 1 Oct 1990

Castellazzi M, Dangy J P, Mechta F, Hirai S, Yaniv M, Samarut J, Lassailly A, Brun G

Abstract excerpt

The coding sequences of avian (quail) or murine c-jun proto-oncogenes were introduced into a non-defective retroviral vector derived from Rous sarcoma virus (RSV) in which c-jun replaces v-src. Primary avian fibroblasts chronically infected with either one of these viruses exhibit some phenotypic traits characteristic of RSV-transformed cells, including sustained growth in low serum medium and ability to develop...

Topics

Amino Acid Sequence
Animals
Cell Division
Cell Transformation, Neoplastic
Cells, Cultured
Chick Embryo
Chickens
DNA-Binding Proteins
Fibroblasts
Kinetics
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Phenotype

Protein-Tyrosine Kinases

Proto-Oncogene Proteins c-jun

Proto-Oncogenes

Quail

Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 2123532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2123532-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Overexpression of avian or mouse c-jun in primary chick embryo fibroblasts confers a partially transformed phenotype.PMID 2123532Read ↗

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