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Article

Overexpression of avian or mouse c-jun in primary chick embryo fibroblasts confers a partially transformed phenotype.

Oncogene - 1 Oct 1990

Castellazzi M, Dangy J P, Mechta F, Hirai S, Yaniv M, Samarut J, Lassailly A, Brun G

Abstract excerpt

The coding sequences of avian (quail) or murine c-jun proto-oncogenes were introduced into a non-defective retroviral vector derived from Rous sarcoma virus (RSV) in which c-jun replaces v-src. Primary avian fibroblasts chronically infected with either one of these viruses exhibit some phenotypic traits characteristic of RSV-transformed cells, including sustained growth in low serum medium and ability to develop...

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PMID: 2123532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Overexpression of avian or mouse c-jun in primary chick embryo fibroblasts confers a partially transformed phenotype.PMID 2123532Read ↗

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.Semantic proximity Read ↗

Cellular Transformation and Malignancy Induced by ras Require c-junSemantic proximity Read ↗

Analysis of AP-1 function in cellular transformation pathways.Semantic proximity Read ↗

Conditional cell transformation by doxycycline-controlled expression of the ASV17 v-jun allele.Semantic proximity Read ↗

Jun, the oncoprotein.Semantic proximity Read ↗

Mitogenesis of quiescent chick fibroblasts by v-Src: dependence on events at the membrane leading to early changes in AP-1.Semantic proximity Read ↗

Chimeric c-Jun containing an heterologous homodimerization domain transforms primary chick embryo fibroblasts.Semantic proximity Read ↗

Transformation suppressor activity of a Jun transcription factor lacking its activation domain.Semantic proximity Read ↗

Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant.Semantic proximity Read ↗

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.Semantic proximity Read ↗

Novel phenotype of C3H 10T1/2 fibroblasts cotransfected with the c-Ha-ras and adenovirus 5 E1A oncogenes.Semantic proximity Read ↗

c-myc gene activation as a permanent trait of RSV-infected quail cells.Semantic proximity Read ↗

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