Article
Fusion of Rous-sarcoma-virus-transformed rat cells to morphologically normal human or rat cells results in transcriptional suppression of the provirus that depends on its chromosomal integration site.
International journal of cancer - 15 Aug 1990
Green A R, Poole C J, Povey S M, Rowe D, Searle S, Wyke J A
Abstract excerpt
The fusion of a Rous sarcoma virus (RSV)-transformed rat fibroblast clone to at least 2 different human cell types reproducibly produces phenotypically normal hybrids. Analysis of such hybrids reveals that proviral silence is the result of transcriptional down-regulation, presumably by a trans-ac...
Topics
- Animals
- Avian Sarcoma Viruses
- Cell Fusion
- Cell Transformation, Viral
- Cells, Cultured
- Chromosomes, Human
- Down-Regulation
- Fibroblasts
- Humans
- Hybrid Cells
- Phenotype