Article
A dominant suppressive mutation in a cellular gene restores the nontransformed phenotype to v-fms-transformed mink cells.
Oncogene - 1 May 1991
Kato J, Sherr C J
Abstract excerpt
A nontransformed revertant subclone (GVR17) was isolated from mutagen-treated populations of mink epithelial cells which had been transformed by the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The revertant cells, although contact-inhibited for growth and unable to form colonies in semisolid medium, contained two copies of integrated SM-FeSV proviral DNA, expressed high levels of the v-fms oncogene...
Topics
- Animals
- Cell Fusion
- Cell Line
- Cell Transformation, Neoplastic
- Genes, Dominant
- Genes, fms
- Mice
- Mice, Nude
- Mink
- Mutation
- Neoplasm Transplantation
- Oncogenes