Article
Analysis of AP-1 function in cellular transformation pathways.
Journal of virology - 1 Jun 1994
Suzuki T, Murakami M, Onai N, Fukuda E, Hashimoto Y, Sonobe M H, Kameda T, Ichinose M, Miki K, Iba H
Abstract excerpt
To understand the role of endogenous AP-1 activity in cellular transformation induced by oncogenes, we have made use of a fos mutant (supfos-1) and a jun mutant (supjun-1), either of which can function as a transdominant inhibitor of AP-1-mediated transcriptional regulation. Chicken embryo fibrob...
Topics
- Animals
- Base Sequence
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Chick Embryo
- DNA Primers
- DNA-Binding Proteins
- Fos-Related Antigen-2
- Gene Expression
- Humans
- Molecular Sequence Data
- Mutation
- Oncogenes
- Proto-Oncogene Proteins c-jun
- Proto-Oncogenes
- Transcription Factors
- Transcription, Genetic