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Article

Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France.

Emerging infectious diseases - 1 Aug 2007

Groschup Martin H, Lacroux Caroline, Buschmann Anne, Lühken Gesine, Mathey Jacinthe, Eiden Martin, Lugan Séverine, Hoffmann Christine, Espinosa Juan Carlos, Baron Thierry, Torres Juan Maria, Erhardt Georg, Andreoletti Olivier

Abstract excerpt

In the past, natural scrapie and bovine spongiform encephalopathy (BSE) infections have essentially not been diagnosed in sheep homozygous for the A136R154R171 haplotype of the prion protein. This genotype was therefore assumed to confer resistance to BSE and classic scrapie under natural exposure conditions. Hence, to exclude prions from the human food chain, massive breeding efforts have been undertaken in the...

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Identifiers

PMID: 17953092
DOI: 10.3201/eid1308.070077
PMCID: PMC2828083

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Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France.PMID 17953092Read ↗

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