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Article

Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication.

The Journal of cell biology - 13 Jun 2011

Kumagai Akiko, Shevchenko Anna, Shevchenko Andrej, Dunphy William G

Abstract excerpt

Treslin, a TopBP1-interacting protein, is necessary for deoxyribonucleic acid (DNA) replication in vertebrates. Association between Treslin and TopBP1 requires cyclin-dependent kinase (Cdk) activity in Xenopus laevis egg extracts. We investigated the mechanism and functional importance of Cdk for this interaction using both X. laevis egg extracts and human cells. We found that Treslin also associated with TopBP1...

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Identifiers

PMID: 21646402
DOI: 10.1083/jcb.201102003
PMCID: PMC3115804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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