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Article

Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response.

The Journal of biological chemistry - 28 Jun 2013

Hassan Bachar H, Lindsey-Boltz Laura A, Kemp Michael G, Sancar Aziz

Abstract excerpt

TopBP1 (topoisomerase IIβ-binding protein 1) is a dual replication/checkpoint protein. Treslin/Ticrr, an essential replication protein, was discovered as a binding partner for TopBP1 and also in a genetic screen for checkpoint regulators in zebrafish. Treslin is phosphorylated by CDK2/cyclin E in a cell cycle-dependent manner, and its phosphorylation state dictates its interaction with TopBP1. The role of Treslin...

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Source

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Identifiers

PMID: 23696651
DOI: 10.1074/jbc.M113.475517
PMCID: PMC3696666

Genes

ATR
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response.PMID 23696651Read ↗

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.Semantic proximity Read ↗

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Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Semantic proximity Read ↗

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Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.Semantic proximity Read ↗

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