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Article

E2A proteins enforce a proliferation checkpoint in developing thymocytes.

The EMBO journal - 14 Jan 2004

Engel Isaac, Murre Cornelis

Abstract excerpt

E2A proteins regulate multiple stages of thymocyte development and suppress T-cell lymphoma. The activity of E2A proteins throughout thymocyte development is modulated by signals emanating from the pre-TCR and TCR. Here we demonstrate that E2A is required for the complete arrest in both differentiation and proliferation observed in thymocytes with defects in proteins that mediate pre-TCR signaling, including LAT,...

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Source

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Identifiers

PMID: 14685278
DOI: 10.1038/sj.emboj.7600017
PMCID: PMC1271657

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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