Article
Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase.
Molecular and cellular biology - 1 Mar 2003
Zheng Lianxing, Dominski Zbigniew, Yang Xiao-Cui, Elms Phillip, Raska Christy S, Borchers Christoph H, Marzluff William F
Abstract excerpt
The replication-dependent histone mRNAs, the only eukaryotic mRNAs that do not have poly(A) tails, are present only in S-phase cells. Coordinate posttranscriptional regulation of histone mRNAs is mediated by the stem-loop at the 3' end of histone mRNAs. The protein that binds the 3' end of histone mRNA, stem-loop binding protein (SLBP), is required for histone pre-mRNA processing and is involved in multiple...
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