Article
Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 2000
Nakanishi M, Ando H, Watanabe N, Kitamura K, Ito K, Okayama H, Miyamoto T, Agui T, Sasaki M
Abstract excerpt
BACKGROUND: In eukaryotic cells, the kinase activity of the mitosis-promoting complex composed of cyclin B and Cdc2 (Cdk1) is negatively regulated by the phosphorylation of Cdk1 on threonine or tyrosine residues within its ATP binding domain. RESULTS: We identified human Wee1B by searching a sequence database. The predicted human Wee1B protein comprises 561 amino acids. Northern blot analysis revealed that human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.