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Article

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.

Genes & development - 15 Sept 1999

Singer J D, Gurian-West M, Clurman B, Roberts J M

Abstract excerpt

Cyclin E is an unstable protein that is degraded in a ubiquitin- and proteasome- dependent pathway. Two factors stimulate cyclin E ubiquitination in vivo: when it is free of its CDK partner, and when it is phosphorylated on threonine 380. We pursued the first of these pathways by using a two-hybrid screen to identify proteins that could bind only to free cyclin E. This resulted in the isolation of human Cul-3, a...

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Identifiers

PMID: 10500095
DOI: 10.1101/gad.13.18.2375
PMCID: PMC317026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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