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Article

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.

Genes & development - 15 Jan 2010

Sansam Christopher L, Cruz Nelly M, Danielian Paul S, Amsterdam Adam, Lau Melissa L, Hopkins Nancy, Lees Jacqueline A

Abstract excerpt

Eukaryotes have numerous checkpoint pathways to protect genome fidelity during normal cell division and in response to DNA damage. Through a screen for G2/M checkpoint regulators in zebrafish, we identified ticrr (for TopBP1-interacting, checkpoint, and replication regulator), a previously uncharacterized gene that is required to prevent mitotic entry after treatment with ionizing radiation. Ticrr deficiency is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20080954
DOI: 10.1101/gad.1860310
PMCID: PMC2807353

Genes

TICRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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