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Article

Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation.

Genes & development - 1 Mar 2015

Sansam Courtney G, Goins Duane, Siefert Joseph C, Clowdus Emily A, Sansam Christopher L

Abstract excerpt

S-phase cyclin-dependent kinases (CDKs) stimulate replication initiation and accelerate progression through the replication timing program, but it is unknown which CDK substrates are responsible for these effects. CDK phosphorylation of the replication factor TICRR (TopBP1-interacting checkpoint and replication regulator)/TRESLIN is required for DNA replication. We show here that phosphorylated TICRR is limiting...

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Source

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Identifiers

PMID: 25737283
DOI: 10.1101/gad.246827.114
PMCID: PMC4358407

Genes

TICRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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