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Article

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation.

The Journal of biological chemistry - 23 Apr 2004

Liu Enbo, Li Xianghong, Yan Feng, Zhao Qiping, Wu Xiaohua

Abstract excerpt

Eukaryotic cells tightly control DNA replication so that replication origins fire only once during S phase within the same cell cycle. Cell cycle-regulated degradation of the replication licensing factor Cdt1 plays important roles in preventing more than one round of DNA replication per cell cycle. We have previously shown that the SCF(Skp2)-mediated ubiquitination pathway plays an important role in Cdt1...

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Identifiers

PMID: 15004027
DOI: 10.1074/jbc.C300549200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation.PMID 15004027Read ↗

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Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.Semantic proximity Read ↗

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.Semantic proximity Read ↗

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