BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects.

doi:10.1038/mp.2011.51

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects.

Molecular psychiatry - 1 Jun 2012

Gerritsen L, Tendolkar I, Franke B, Vasquez A A, Kooijman S, Buitelaar J, Fernández G, Rijpkema M

Abstract excerpt

According to the neurotrophic hypothesis of depression, stress can lead to brain atrophy by modifying brain-derived neurotrophic factor (BDNF) levels. Given that BDNF secretion is affected by a common polymorphism (rs6265, Val66Met), which also is associated with depression, we investigated whether this polymorphism modifies the effect of childhood adversity (CA) on local gray matter (GM) volume in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Atrophy

Share to Brain-Derived Neurotrophic Factor

Share to Brain Mapping

Share to Gyrus Cinguli

Share to Magnetic Resonance Imaging

Share to Self Report

Share to Stress, Psychological

Source

Open in PubMed

Identifiers

PMID: 21577214
DOI: 10.1038/mp.2011.51

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects.PMID 21577214Read ↗

The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression.Semantic proximity Read ↗

Gray matter volume in adolescent anxiety: an impact of the brain-derived neurotrophic factor Val(66)Met polymorphism?Semantic proximity Read ↗

Interactive effects of BDNF Val66Met genotype and trauma on limbic brain anatomy in childhood.Semantic proximity Read ↗

Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume.Semantic proximity Read ↗

Interactive effects of genetic polymorphisms and childhood adversity on brain morphologic changes in depression.Semantic proximity Read ↗

BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields.Semantic proximity Read ↗

BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents.Semantic proximity Read ↗

Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects.Semantic proximity Read ↗

Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.Semantic proximity Read ↗

Effects of the BDNF Val66Met Polymorphism on Gray Matter Volume in Typically Developing Children and Adolescents.Semantic proximity Read ↗

Effect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology.Semantic proximity Read ↗

Effect of the BDNF Val66Met polymorphism on regional gray matter volumes and cognitive function in the Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.