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Article

Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2013

Carballedo Angela, Morris Derek, Zill Peter, Fahey Ciara, Reinhold Elena, Meisenzahl Eva, Bondy Brigitta, Gill Michael, Möller Hans-Jürgen, Frodl Thomas

Abstract excerpt

The interaction between adverse life events during childhood and genetic factors is associated with a higher risk to develop major depressive disorder (MDD). One of the polymorphisms found to be associated with MDD is the Val66MET polymorphism of brain-derived neurotrophic factor (BDNF). The aim of our two-center study was to determine how the BDNF Val66Met polymorphism and childhood adversity affect the...

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Identifiers

PMID: 23341118
DOI: 10.1002/ajmg.b.32130

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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