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Article

Effect of the BDNF Val66Met polymorphism on regional gray matter volumes and cognitive function in the Chinese population.

Neuromolecular medicine - 1 Mar 2014

Liu Mu-En, Huang Chu-Chung, Chen Mu-Hong, Yang Albert C, Tu Pei-Chi, Yeh Heng-Liang, Hong Chen-Jee, Chen Jin-Fan, Hwang Jen-Ping, Lin Ching-Po, Tsai Shih-Jen

Abstract excerpt

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is common and influences the activity-dependent secretion of BDNF, which is critical for neuronal plasticity and survival. This study investigated the genetic effect of the BDNF Val66Met polymorphism on cognitive function and regional gray matter (GM) volume in a healthy Chinese population (n = 330). Voxel-based morphometry (VBM)-optimized...

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PMID: 24366608
DOI: 10.1007/s12017-013-8265-7

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BDNF

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