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Article

Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Oct 2008

Sublette M E, Baca-Garcia Enrique, Parsey Ramin V, Oquendo Maria A, Rodrigues Sarina M, Galfalvy Hanga, Huang Yung-Yu, Arango Victoria, Mann J J

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) has been implicated in the mechanism of age-related regional brain volumetric changes. Healthy volunteers with the valine to methionine polymorphism at codon 66 of the BDNF gene (val66met) exhibit decreased volume of a number of brain structures, including hippocampus, temporal and occipital lobar gray matter volumes, and a negative correlation between age and the volume...

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Identifiers

PMID: 18621091
DOI: 10.1016/j.pnpbp.2008.06.009
PMCID: PMC2674019

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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