Article
Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 May 2011
Braskie Meredith N, Jahanshad Neda, Stein Jason L, Barysheva Marina, McMahon Katie L, de Zubicaray Greig I, Martin Nicholas G, Wright Margaret J, Ringman John M, Toga Arthur W, Thompson Paul M
Abstract excerpt
There is a strong genetic risk for late-onset Alzheimer's disease (AD), but so far few gene variants have been identified that reliably contribute to that risk. A newly confirmed genetic risk allele C of the clusterin (CLU) gene variant rs11136000 is carried by ∼88% of Caucasians. The C allele confers a 1.16 greater odds of developing late-onset AD than the T allele. AD patients have reductions in regional white...
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