Article
Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Dec 2011
Erk Susanne, Meyer-Lindenberg Andreas, Opitz von Boberfeld Carola, Esslinger Christine, Schnell Knut, Kirsch Peter, Mattheisen Manuel, Mühleisen Thomas W, Cichon Sven, Witt Stephanie H, Rietschel Marcella, Nöthen Markus M, Walter Henrik
Abstract excerpt
Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory...
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