Article
Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2026
Lorenz Anna S, Sathe Aditi, Yang Yisu, Durant Alaina, Wu Yiyang, Kim Michael E, Gao Chenyu, Newlin Nancy R, Ramadass Karthik, Kanakaraj Praitayini, Khairi Nazirah Mohd, Li Zhiyuan, Yao Tianyuan, Huo Yuankai, Dumitrescu Logan, Shashikumar Niranjana, Pechman Kimberly R, Risacher Shannon L, Beason-Held Lori L, An Yang, Arfanakis Konstantinos, Erus Guray, Davatzikos Christos, Habes Mohamad, Wang Di, Tosun Duygu, Toga Arthur W, Thompson Paul M, Mormino Elizabeth C, Zhang Panpan, Schilling Kurt, Albert Marilyn, Kukull Walter, Biber Sarah A, Landman Bennett A, Johnson Sterling C, Bendlin Barbara, Schneider Julie, Bennett David A, Jefferson Angela L, Resnick Susan M, Saykin Andrew J, Below Jennifer E, Hohman Timothy J, Archer Derek B
Abstract excerpt
INTRODUCTION: Limbic white matter (WM) abnormalities are prevalent in aging and Alzheimer's disease (AD), but genetic drivers are unclear. METHODS: In 2614 older adults (mean age ± SD: 73.7 ± 9.8 years; 26% cognitively impaired) from seven harmonized cohorts enriched for cognitive impairment, we quantified free-water-corrected diffusion MRI (dMRI) metrics in seven limbic tracts. We estimated single nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.