Article

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer’s Disease

2025-05-21

Abstract excerpt

<h4>Background</h4> Limbic white matter (WM) abnormalities are prevalent in aging and Alzheimer’s disease (AD), yet their underlying biological mechanisms remain unclear. This study aims to identify the genetic architecture of limbic WM microstructure in older adults by leveraging harmonized data from multiple cohorts, including those enriched for cognitively impaired individuals. <h4>Methods</h4> We analyzed diff...

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Literature Corpus work: 5f45e9df-2c31-5450-85e8-6b7aa63e4bf7
DOI: 10.1101/2025.05.19.25327915

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