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Article

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.

Scientific reports - 27 May 2016

Tan Lin, Wang Hui-Fu, Tan Meng-Shan, Tan Chen-Chen, Zhu Xi-Chen, Miao Dan, Yu Wan-Jiang, Jiang Teng, Tan Lan, Yu Jin-Tai

Abstract excerpt

The Clusterin (CLU) gene, also known as apolipoprotein J (ApoJ), is currently the third most associated late-onset Alzheimer's disease (LOAD) risk gene. However, little was known about the possible effect of CLU genetic variants on AD pathology in brain. Here, we evaluated the interaction between 7 CLU SNPs (covering 95% of genetic variations) and the role of CLU in β-amyloid (Aβ) deposition, AD-related structure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27229352
DOI: 10.1038/srep26027
PMCID: PMC4882617

Genes

CLU

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