Genetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene.

doi:10.2174/1567205013666160703180531

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Article

Genetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene.

Current Alzheimer research - 1 Jan 2016

Qiu Lihua, He Yong, Tang Hehan, Zhou Yi, Wang Jinhong, Zhang Weiwei, Chen Guangxiang, Zhao Fei, Ouyang Tingxue, Ju Bin, Li Zhengyan, Wang Lanlan, Zou Ling, Gong Qiyong

Abstract excerpt

BACKGROUND: Several genome-wide association studies have found that the rs11136000 polymorphism of the C allele (CLU-C) is associated with the risk for developing late-onset Alzheimer's disease (LOAD). However, the effects of the CLU-C/C genotype on brain structure, including gray and white matter, are not adequately understood. OBJECTIVES: We aimed to clarify the gray matter and white matter integrity changes in...

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PMID: 27396407
DOI: 10.2174/1567205013666160703180531
PMCID: PMC5112753

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