Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly.

doi:10.1523/JNEUROSCI.5236-13.2014

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Article

Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 May 2014

Roussotte Florence F, Gutman Boris A, Madsen Sarah K, Colby John B, Thompson Paul M

Abstract excerpt

The C allele at the rs11136000 locus in the clusterin (CLU) gene is the third strongest known genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent genome-wide association study of LOAD found the strongest evidence of association with CLU at rs1532278, in high linkage disequilibrium with rs11136000. Brain structure and function are related to the CLU risk alleles, not just in LOAD patients but...

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PMID: 24806679
DOI: 10.1523/JNEUROSCI.5236-13.2014
PMCID: PMC4012312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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