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Article

Serum cholesterol and variant in cholesterol-related gene CETP predict white matter microstructure.

Neurobiology of aging - 1 Nov 2014

Warstadt Nicholus M, Dennis Emily L, Jahanshad Neda, Kohannim Omid, Nir Talia M, McMahon Katie L, de Zubicaray Greig I, Montgomery Grant W, Henders Anjali K, Martin Nicholas G, Whitfield John B, Jack Clifford R, Bernstein Matt A, Weiner Michael W, Toga Arthur W, Wright Margaret J, Thompson Paul M

Abstract excerpt

Several common genetic variants influence cholesterol levels, which play a key role in overall health. Myelin synthesis and maintenance are highly sensitive to cholesterol concentrations, and abnormal cholesterol levels increase the risk for various brain diseases, including Alzheimer's disease. We report significant associations between higher serum cholesterol (CHOL) and high-density lipoprotein levels and...

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Identifiers

PMID: 24997672
DOI: 10.1016/j.neurobiolaging.2014.05.024
PMCID: PMC4198330

Genes

CETP

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