Alzheimer's disease risk variant in CLU is associated with neural inefficiency in healthy individuals.

doi:10.1016/j.jalz.2014.10.012

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Alzheimer's disease risk variant in CLU is associated with neural inefficiency in healthy individuals.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2015

Lancaster Thomas M, Brindley Lisa M, Tansey Katherine E, Sims Rebecca C, Mantripragada Kiran, Owen Michael J, Williams Julie, Linden David E J

Abstract excerpt

INTRODUCTION: Genome-wide association studies identify rs11136000 in the CLU gene, which codes for Apolipoprotein J/Clusterin, as a significant risk variant for Alzheimer's disease (AD). However, the mechanisms by which this variant confers susceptibility remain relatively unknown. METHODS: Eighty-five healthy Caucasian participants underwent functional magnetic resonance imaging during a working memory (WM) task...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clusterin

Share to Genome-Wide Association Study

Share to Hippocampus

Share to Magnetic Resonance Imaging

Share to Memory, Short-Term

Share to Nerve Net

Share to Young Adult

Source

Open in PubMed

Identifiers

PMID: 25496871
DOI: 10.1016/j.jalz.2014.10.012

Genes

CLU
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer's disease risk variant in CLU is associated with neural inefficiency in healthy individuals.PMID 25496871Read ↗

Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant.Semantic proximity Read ↗

Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults.Semantic proximity Read ↗

Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene.Semantic proximity Read ↗

A gene-brain-cognition pathway for the effect of an Alzheimer׳s risk gene on working memory in young adults.Semantic proximity Read ↗

Genetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene.Semantic proximity Read ↗

Alzheimer risk variant CLU and brain function during aging.Semantic proximity Read ↗

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.Semantic proximity Read ↗

Associations between CLU polymorphisms and memory performance: The role of serum lipids in Alzheimer's disease.Semantic proximity Read ↗

Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly.Semantic proximity Read ↗

Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults.Semantic proximity Read ↗

The selective vulnerability of the left fimbria in cognitively normal APOE ε4 carriers: a localized structural correlate of high genetic risk for Alzheimer's disease.Semantic proximity Read ↗

Association of rs1006737 in CACNA1C with alterations in prefrontal activation and fronto-hippocampal connectivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.