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Article

Downregulation of protein kinase C-gamma is independent of a functional kinase domain.

FEBS letters - 25 Mar 1991

Freisewinkel I, Riethmacher D, Stabel S

Abstract excerpt

Prolonged activation of protein kinase C (PKC) types alpha and beta by tumor-promoting phorbol esters leads to desensitization of the phorbol ester response, downregulation of protein kinase C activity and depletion of the protein kinase C polypeptide. When the gamma isoenzyme of PKC is transiently expressed in COS-1 cells and exposed to phorbol esters, PKC-Gamma is downregulated in COS cells although these cells...

Topics

Adenosine Triphosphate
Animals
Baculoviridae
Cells, Cultured
Down-Regulation
Enzyme Activation
Isoenzymes
Lysine
Methionine
Mutation
Phorbol Esters
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Protein Kinase C

Transfection

Source

Identifiers

PMID: 1901548
DOI: 10.1016/0014-5793(91)80307-o

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1901548-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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