Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.

doi:10.1002/j.1460-2075.1991.tb07739.x

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Article

Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.

The EMBO journal - 1 Aug 1991

Peles E, Levy R B, Or E, Ullrich A, Yarden Y

Abstract excerpt

The neu/HER2 proto-oncogene encodes a transmembrane tyrosine kinase homologous to receptors for polypeptide growth factors. The oncogenic potential for the presumed receptor is released through multiple genetic mechanisms including a specific point mutation, truncation at the extracellular domain and overexpression of the protooncogene. Here we show that all these modes of oncogenic activation result in a...

Topics

Base Sequence
Blotting, Western
Cell Transformation, Neoplastic
Electrophoresis, Polyacrylamide Gel
Humans
Molecular Sequence Data
Mutation
Phosphatidylinositols
Phosphorylation
Precipitin Tests
Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Mas

Proto-Oncogene Proteins

Receptor, ErbB-2

Tumor Cells, Cultured

Type C Phospholipases

Vanadates

Source

Open in PubMed Open full text

Identifiers

PMID: 1676673
DOI: 10.1002/j.1460-2075.1991.tb07739.x
PMCID: PMC452891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1676673-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.PMID 1676673Read ↗

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