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Article

Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.

The EMBO journal - 1 Aug 1991

Peles E, Levy R B, Or E, Ullrich A, Yarden Y

Abstract excerpt

The neu/HER2 proto-oncogene encodes a transmembrane tyrosine kinase homologous to receptors for polypeptide growth factors. The oncogenic potential for the presumed receptor is released through multiple genetic mechanisms including a specific point mutation, truncation at the extracellular domain and overexpression of the protooncogene. Here we show that all these modes of oncogenic activation result in a...

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Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 1676673
DOI: 10.1002/j.1460-2075.1991.tb07739.x
PMCID: PMC452891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.PMID 1676673Read ↗

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