Article
Distinct structural specificities for functional coupling of the epidermal growth factor receptor to calcium-signalling versus phospholipase A2 responses.
The Biochemical journal - 1 May 1991
Hack N, Margolis B L, Ullrich A, Schlessinger J, Skorecki K L
Abstract excerpt
Activation of phospholipase C (PLC), leading to a rise in cytosolic Ca2+, and of phospholipase A2 (PLA2) leading to a release of arachidonic acid, are among the early transmembrane signalling events that have been demonstrated in response to occupancy of the epidermal growth factor (EGF) receptor. The tyrosine kinase activity of the receptor has been shown to be necessary for both of these responses. This...
Topics
- Arachidonic Acid
- Arachidonic Acids
- Binding Sites
- Calcimycin
- Calcium
- Cell Line
- Cell Membrane Permeability
- Cytosol
- ErbB Receptors
- Mutation
- Peptide Fragments