Constitutive phosphorylation of the epidermal growth factor receptor blocks mitogenic signal transduction.

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Article

Constitutive phosphorylation of the epidermal growth factor receptor blocks mitogenic signal transduction.

The Journal of biological chemistry - 15 Jan 1991

Bowen S, Stanley K, Selva E, Davis R J

Abstract excerpt

The epidermal growth factor (EGF) receptor is phosphorylated by protein kinase C at Thr654. It has been proposed that the phosphorylation of this site is an important regulatory mechanism for the control of EGF receptor function. However, the physiological significance of the phosphorylation of E...

Topics

Animals
Autoradiography
Cells, Cultured
Chromatography, High Pressure Liquid
Cricetinae
Cricetulus
Enzyme Activation
ErbB Receptors
Mitogens
Mutation
Phosphorylation
Plasmids
Protein Kinase C
Signal Transduction
Tetradecanoylphorbol Acetate
Threonine
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 1898731

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1898731-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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