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Article

Constitutive phosphorylation of the epidermal growth factor receptor blocks mitogenic signal transduction.

The Journal of biological chemistry - 15 Jan 1991

Bowen S, Stanley K, Selva E, Davis R J

Abstract excerpt

The epidermal growth factor (EGF) receptor is phosphorylated by protein kinase C at Thr654. It has been proposed that the phosphorylation of this site is an important regulatory mechanism for the control of EGF receptor function. However, the physiological significance of the phosphorylation of EGF receptor Thr654 in intact cells is not understood. To address this question, the design of an experimental strategy...

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Identifiers

PMID: 1898731

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Constitutive phosphorylation of the epidermal growth factor receptor blocks mitogenic signal transduction.PMID 1898731Read ↗

Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor.Semantic proximity Read ↗

Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase.Semantic proximity Read ↗

Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation.Semantic proximity Read ↗

Effects of substitution of threonine 654 of the epidermal growth factor receptor on epidermal growth factor-mediated activation of phospholipase C.Semantic proximity Read ↗

Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.Semantic proximity Read ↗

Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates.Semantic proximity Read ↗

Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site.Semantic proximity Read ↗

Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation.Semantic proximity Read ↗

Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites.Semantic proximity Read ↗

Regulation of EGF receptor expression and function.Semantic proximity Read ↗

Stimulation of mitogenic pathways through kinase-impaired mutants of the epidermal growth factor receptor.Semantic proximity Read ↗

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.Semantic proximity Read ↗

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