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Article

The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling.

The Journal of biological chemistry - 16 May 2003

Jang Il Ho, Lee Sukmook, Park Jong Bae, Kim Jong Hyun, Lee Chang Sup, Hur Eun-Mi, Kim Il Shin, Kim Kyong-Tai, Yagisawa Hitoshi, Suh Pann-Ghill, Ryu Sung Ho

Abstract excerpt

The epidermal growth factor (EGF) receptor has an important role in cellular proliferation, and the enzymatic activity of phospholipase C (PLC)-gamma1 is regarded to be critical for EGF-induced mitogenesis. In this study, we report for the first time a phospholipase complex composed of PLC-gamma1 and phospholipase D2 (PLD2). PLC-gamma1 is co-immunoprecipitated with PLD2 in COS-7 cells. The results of in vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12646582
DOI: 10.1074/jbc.M208438200

Genes

PLD2
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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