Article
Effects of substitution of threonine 654 of the epidermal growth factor receptor on epidermal growth factor-mediated activation of phospholipase C.
The Journal of biological chemistry - 25 Apr 1990
Decker S J, Ellis C, Pawson T, Velu T
Abstract excerpt
Addition of epidermal growth factor (EGF) to many cell types activates phospholipase C resulting in increased levels of diacylglycerol and intracellular Ca2+ which may lead to activation of protein kinase C. EGF treatment of cells can also lead to phosphorylation of the EGF receptor at threonine...
Topics
- Animals
- Cells, Cultured
- Enzyme Activation
- Epidermal Growth Factor
- ErbB Receptors
- Humans
- Inositol Phosphates
- Kinetics
- Mice
- Mutation
- Peptide Mapping
- Phosphopeptides
- Phosphorylation
- Plasmids
- Tetradecanoylphorbol Acetate
- Threonine
- Transfection
- Type C Phospholipases