Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Universally conserved and yeast-specific U1 snRNA sequences are important but not essential for U1 snRNP function.

Genes & development - 1 Oct 1990

Liao X L, Kretzner L, Seraphin B, Rosbash M

Abstract excerpt

To study the contribution of the large, 568-nucleotide yeast (Saccharomyces cerevisiae) U1 snRNA to pre-mRNA splicing, we generated mutations in two regions of the molecule and introduced each mutant gene back into yeast as the sole copy of the U1 snRNA gene. We mutagenized the "A loop," a subregion highly conserved in primary sequence in all U1 snRNA molecules analyzed to date. We also mutagenized a portion of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Fungal Proteins
Share to Molecular Sequence Data

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Plasmids

Share to RNA, Messenger

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 2147421
DOI: 10.1101/gad.4.10.1766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Universally conserved and yeast-specific U1 snRNA sequences are important but not essential for U1 snRNP function.PMID 2147421Read ↗

More than half of yeast U1 snRNA is dispensable for growth.Semantic proximity Read ↗

An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing.Semantic proximity Read ↗

Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.Semantic proximity Read ↗

The central region of the yeast U4 snRNA is not important for hammerhead catalysis, but may act as a domain spacer.Semantic proximity Read ↗

A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins.Semantic proximity Read ↗

The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.Semantic proximity Read ↗

Construction of an in vivo-regulated U6 snRNA transcription unit as a tool to study U6 function.Semantic proximity Read ↗

Mutations in U5 snRNA loop 1 influence the splicing of different genes in vivo.Semantic proximity Read ↗

Characterization of yeast U1 snRNP A protein: identification of the N-terminal RNA binding domain (RBD) binding site and evidence that the C-terminal RBD functions in splicing.Semantic proximity Read ↗

The phylogenetically invariant ACAGAGA and AGC sequences of U6 small nuclear RNA are more tolerant of mutation in human cells than in Saccharomyces cerevisiae.Semantic proximity Read ↗

Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors.Semantic proximity Read ↗

Mutations at the 3' splice site can be suppressed by compensatory base changes in U1 snRNA in fission yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.