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Article

Mutations in U5 snRNA loop 1 influence the splicing of different genes in vivo.

Nucleic acids research - 15 Dec 2002

O'Keefe Raymond T

Abstract excerpt

The U5 snRNA loop 1 is characterized by the conserved sequence G1C2C3U4U5U6Y7A8Y9 and is essential for the alignment of exons during the second step of pre-mRNA splicing in Saccharo myces cerevisiae. Despite this sequence conservation the size, rather than sequence, of loop 1 is critical for exon alignment in vitro. To determine the in vivo requirements for U5 loop 1 a library of loop 1 sequences was transformed...

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Identifiers

PMID: 12490716
DOI: 10.1093/nar/gkf692
PMCID: PMC140076

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Research trail→

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Mutations in U5 snRNA loop 1 influence the splicing of different genes in vivo.PMID 12490716Read ↗

Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8.Semantic proximity Read ↗

Universally conserved and yeast-specific U1 snRNA sequences are important but not essential for U1 snRNP function.Semantic proximity Read ↗

A conditional U5 snRNA mutation affecting pre-mRNA splicing and nuclear pre-mRNA retention identifies SSD1/SRK1 as a general splicing mutant suppressor.Semantic proximity Read ↗

Mutations at the 3' splice site can be suppressed by compensatory base changes in U1 snRNA in fission yeast.Semantic proximity Read ↗

Mutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre-mRNA splicing.Semantic proximity Read ↗

More than half of yeast U1 snRNA is dispensable for growth.Semantic proximity Read ↗

Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors.Semantic proximity Read ↗

Conserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts.Semantic proximity Read ↗

A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.Semantic proximity Read ↗

The U5 snRNA internal loop 1 is a platform for Brr2, Snu114 and Prp8 protein binding during U5 snRNP assembly.Semantic proximity Read ↗

An intronic RNA structure modulates expression of the mRNA biogenesis factor Sus1.Semantic proximity Read ↗

Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits.Semantic proximity Read ↗

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