Article
The phylogenetically invariant ACAGAGA and AGC sequences of U6 small nuclear RNA are more tolerant of mutation in human cells than in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Sept 1993
Datta B, Weiner A M
Abstract excerpt
U6 small nuclear RNA (snRNA) is the most highly conserved of the five spliceosomal snRNAs that participate in nuclear mRNA splicing. The proposal that U6 snRNA plays a key catalytic role in splicing [D. Brow and C. Guthrie, Nature (London) 337:14-15, 1989] is supported by the phylogenetic conserv...
Topics
- Base Sequence
- DNA Mutational Analysis
- Humans
- Molecular Sequence Data
- Mutation
- RNA Splicing
- RNA, Fungal
- RNA, Small Nuclear
- Saccharomyces cerevisiae
- Species Specificity
- Structure-Activity Relationship
- Transfection