Article
An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing.
Genes & development - 1 Mar 1993
Liao X C, Tang J, Rosbash M
Abstract excerpt
In an enhancer screen for yeast mutants that may interact with U1 small nuclear RNA (snRNA), we identified a gene that encodes the apparent yeast homolog of the well-studied human U1A protein. Both in vitro and in vivo, the absence of the protein has a dramatic effect on the activity of U1 snRNP...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Escherichia coli
- Genes, Fungal
- Humans
- Models, Genetic
- Models, Structural
- Molecular Sequence Data
- Mutagenesis, Insertional
- Nucleic Acid Conformation
- Oligodeoxyribonucleotides
- Open Reading Frames
- Polymerase Chain Reaction
- Protein Structure, Secondary
- RNA Precursors
- RNA Splicing