Article
A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins.
RNA (New York, N.Y.) - 1 Apr 1998
Gottschalk A, Tang J, Puig O, Salgado J, Neubauer G, Colot H V, Mann M, Séraphin B, Rosbash M, Lührmann R, Fabrizio P
Abstract excerpt
The U1 snRNP is essential for recognition of the pre-mRNA 5'-splice site and the subsequent assembly of the spliceosome. Yeast U1 snRNP is considerably more complex than its metazoan counterpart, which suggests possible differences between yeast and metazoa in early splicing events. We have compr...
Topics
- Amino Acid Sequence
- Autoantigens
- Cloning, Molecular
- Fungal Proteins
- Mass Spectrometry
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Protein Binding
- RNA-Binding Proteins
- Ribonucleoprotein, U1 Small Nuclear
- Ribonucleoproteins, Small Nuclear
- Saccharomyces cerevisiae