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Article

A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins.

RNA (New York, N.Y.) - 1 Apr 1998

Gottschalk A, Tang J, Puig O, Salgado J, Neubauer G, Colot H V, Mann M, Séraphin B, Rosbash M, Lührmann R, Fabrizio P

Abstract excerpt

The U1 snRNP is essential for recognition of the pre-mRNA 5'-splice site and the subsequent assembly of the spliceosome. Yeast U1 snRNP is considerably more complex than its metazoan counterpart, which suggests possible differences between yeast and metazoa in early splicing events. We have comprehensively analyzed the composition of yeast U1 snRNPs using a combination of biochemical, mass spectrometric, and...

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Identifiers

PMID: 9630245
PMCID: PMC1369625

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